Biological activity

AEBSF hydrochloride is an irreversible inhibitor of serine proteases, capable of inhibiting enzymes such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

In vitro study

AEBSFinhibitstheconstitutiveproductionofAβbydirectlyinhibitingβ-secretaseinfivedifferenthumancelllines,bothneuralandnonneural.AEBSF,asaserineproteaseinhibitor,inhibitsthelysisofleukemiccellsbyhumanmacrophageswithoutinhibitingmacrophagesecretionofTNF-αandIL-1β.AEBSFalsodisturbsthegrowthofblastocystsonendometrialcellsandinhibitChemicalbooktheadhesionofHeLacellsonHUVECsbyalteringtheproteinsecretionpattern.

In vivo study

AEBSF(76.8mg/kgdaily,i.p.)resultsinprolongationofthesurvivalofmicethathavebeengivenalethalT.gondiiinfection.AEBSFalsoreducesairwayresponseandunderlyinginflammationincockroachallergen-inducedmurinemodel.

Purpose/Use

It is recommended to use a concentration of 0.1 to 1 mM.

Purpose/Use

As an irreversible serine protease inhibitor, it is used for cell culture

Purpose/Use

It is recommended to use an irreversible serine protease inhibitor at a concentration of 0.1-1 mM. This inhibitor can inhibit trypsin, chymotrypsin, plasmin, thrombin, and kallikrein. It is soluble in water, and its aqueous solution at pH 7 remains stable for 1-2 months at 4°C.